XEOMIN® is a prescription medication used in facial aesthetics to temporarily improve the appearance of moderate to severe glabellar frown lines between the eyes (glabellar lines) in adults. XEOMIN® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.

XEOMIN® is also sometimes referred to as incobotulinumtoxina.

How Does it Work?
When you squint or frown, the muscles between your brows contract, causing the skin to furrow and fold. These lines that occur due to facial mimics are referred to as dynamic lines. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines.
Botulinum toxin type A – the active ingredient in XEOMIN® – is used in facial aesthetic treatment to treat dynamic lines like glabellar frown lines. It acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN® can temporarily reduce the frown lines on your forehead between your eyes.

XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use, was proven effective in two randomized, double-blind, multicenter, placebo-controlled clinical trials of more than 540 adult patients in the treatment of glabellar frown lines. The average age of patients in the study was 46 years. Patients received 20 Units of XEOMIN® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment success was higher with XEOMIN® than placebo on day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, XEOMIN® received FDA approval for aesthetic use in 2011.

If you are an adult with moderate to severe glabellar lines (frown lines between the eyes), XEOMIN® may be

right for you. Talk to your doctor to discuss the benefits and risks of treatment.
Do not take XEOMIN® if you are allergic to botulinum toxin or any of the other ingredients in XEOMIN®. You should also not take XEOMIN® if you have had an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.
See the difference in frown lines before and after treatment with XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use.

Elisabeth, Age 46
Severe Glabellar Frown Lines

Claudia, Age 39
Severe Glabellar Frown Lines

Cheri, Age 53
Moderate Glabellar Frown Lines

Julie, Age 45
Severe Glabellar Frown Lines

Barbara, Age 38
Moderate Glabellar Frown Lines

Derek, Age 41
Moderate Glabellar Frown Lines

Julie, Age 45
Severe Glabellar Frown Lines

Individual results may vary. Unretouched photos.
The median first onset of XEOMIN® effect occurs within 7 days of injection. Maximum effect occurs at 30 days. The typical duration of effect is up to 3 months, but may last significantly longer or shorter in individual patients. In studies, XEOMIN®-treated subjects ranged from 24 to 74 years of age with an average age of 46.